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Index > Protein center > PROC(Gene name) > Bovine
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  • PROC (Gene name),
  • Vitamin K-dependent protein C (Protein name ),  PROC_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    PROC;
    Protein name:
    Vitamin K-dependent protein C;
    Alternative:
    Autoprothrombin IIA;Anticoagulant protein C;Blood coagulation factor XIV;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
    Function:
    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    456
    Sequence:
    50:
    XTSLLLFVTI | WGISSTPAPP | DSVFSSSQRA | HQVLRIRKRA | NSFLEELRPG | 
    100:
    NVERECSEEV | CEFEEAREIF | QNTEDTMAFW | SFYSDGDQCE | DRPSGSPCDL | 
    150:
    PCCGRGKCID | GLGGFRCDCA | EGWEGRFCLH | EVRFSNCSAE | NGGCAHYCME | 
    200:
    EEGRRHCSCA | PGYRLEDDHQ | LCVSKVTFPC | GRLGKRMEKK | RKTLKRDTNQ | 
    250:
    VDQKDQLDPR | IVDGQEAGWG | ESPWQAVLLD | SKKKLVCGAV | LIHVSWVLTV | 
    300:
    AHCLDSRKKL | IVRLGEYDMR | RWESWEVDLD | IKEVIIHPNY | TKSTSDNDIA | 
    350:
    LLRLAKPATL | SQTIVPICLP | DSGLSERKLT | QVGQETVVTG | WGYRDETKRN | 
    400:
    RTFVLSFIKV | PVVPYNACVH | AMENKISENM | LCAGILGDPR | DACEGDSGGP | 
    450:
    MVTFFRGTWF | LVGLVSWGEG | CGRLYNYGVY | TKVSRYLDWI | YGHIKAQEAP | 
    456:
    LESQVP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Vitamin K-dependent protein C
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    E0734h
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    ELISA Kit for Bovine Vitamin K-dependent protein C
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    ELISA Kit for Bovine Vitamin K-dependent protein C
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    ELISA Kit for Bovine Vitamin K-dependent protein C
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    E0734p
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    ELISA Kit for Bovine Vitamin K-dependent protein C
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    E0734d
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    ELISA Kit for Bovine Vitamin K-dependent protein C
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    ELISA Kit for Bovine Vitamin K-dependent protein C
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    E0734b
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    CLIA Kit for Bovine Vitamin K-dependent protein C
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    U0734m
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    CLIA Kit for Bovine Vitamin K-dependent protein C
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    U0734p
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    96T
    CLIA Kit for Bovine Vitamin K-dependent protein C
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    U0734r
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    CLIA Kit for Bovine Vitamin K-dependent protein C
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    U0734h
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    MSDS:
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    96T
    CLIA Kit for Bovine Vitamin K-dependent protein C
    Cat.:
    U0734d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine Vitamin K-dependent protein C
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    CLIA Kit for Bovine Vitamin K-dependent protein C
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    U0734b
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    Packing:
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    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
    Cat.:
    P0734Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
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    P0734Rb-h
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    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
    Cat.:
    P0734Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
    Polyclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Monoclonal Antibody for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C
    Protein for Bovine Vitamin K-dependent protein C

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    References
    1. 1.
      "Cloning and sequencing of liver cDNA coding for bovine protein C."
      Long G.L. , Balagaje R.M. , McGillivray R.T.A.
      Proc. Natl. Acad. Sci. U.S.A.81:5653-5656(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Amino acid sequence of the light chain of bovine protein C."
      Fernlund P. , Stenflo J.
      J. Biol. Chem.257:12170-12179(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 40-194;GLYCOSYLATION AT ASN-136;HYDROXYLATION AT ASP-110;GAMMA-CARBOXYGLUTAMATION AT GLU-45; GLU-46; GLU-53; GLU-55; GLU-58; GLU-59; GLU-62; GLU-64; GLU-65; GLU-68 AND GLU-74
    3. 3.
      "Beta-hydroxyaspartic acid in vitamin K-dependent protein C."
      Drakenberg T. , Fernlund P. , Roepstorff P. , Stenflo J.
      Proc. Natl. Acad. Sci. U.S.A.80:1802-1806(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 110
    4. 4.
      "Amino acid sequence of the heavy chain of bovine protein C."
      Stenflo J. , Fernlund P.
      J. Biol. Chem.257:12180-12190(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 197-456;GLYCOSYLATION AT ASN-289; ASN-350 AND ASN-366
    5. 5.
      "Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C."
      Esmon N.L. , Debault L.E. , Esmon C.T.
      J. Biol. Chem.258:5548-5553(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;CALCIUM-BINDING
    6. 6.
      "Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid."
      Johnson A.E. , Esmon N.L. , Laue T.M. , Esmon C.T.
      J. Biol. Chem.258:5554-5560(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;CALCIUM-BINDING DATA
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